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Our expertise — Step 4 of 7

Submissions

Securing approvals: a submission strategy tailored to the trial type, driven through to each site's greenlight.

What we do at this step

Submission strategy by trial type

EU Regulation: CTIS Part II

National regulations: ANSM & CPP, CNIL/HDH (France)

AFMPS & Ethics Committees (Belgium)

Initial submissions & amendments, through to greenlight (approval + signed contract)

Scope: European Union (CTIS) · France and Belgium

The roles that can be involved at this step

Start-Up — SSU & Contract Specialist

Feasibility, collection of essential documents, contract & budget negotiation (Convention Unique, Pharma.be), ARS & CNOM notifications, submissions through to greenlight.

Start-Up coordination — SSU Lead

SSU team management, harmonised practices, tracking of start-up milestones across countries.

Investigator site monitoring — Senior CRA

Selection visits, initiation, on-site and remote monitoring, recruitment boosting, site close-out.

Clinical operations coordination — Clinical Trial Lead (CTL)

Steering clinical operations, coordinating CRA teams across countries, sponsor reporting.

Investigator site support — Study Coordinator

Support to site teams: patient visits, eCRF data entry, samples and supplies management.

Project management — project-lead tasks carried as SSU Lead & Clinical Trial Lead

End-to-end project management: planning, budget, risks, sponsor/CRO/site interfaces.

Clinical Oversight — Clinical Oversight Manager

Sponsor-type oversight of vendors (ICH-GCP): oversight plan, sponsor review of monitoring reports & TMF, KPIs/metrics, governance committees & escalation.

Quality

Deviation & CAPA management, preparation and support for audits & inspections.